Structure of GCase-Nb1 complex
Left: Overall structure of the GCase-Nb1 complex. The three domains of GCase are coloured pink (domain 1, a three-stranded anti-parallel β-sheet domain), green (domain 2, an Ig-like domain) and light blue (domain 3, a (β/α)8-TIM barrel). Nb1 is coloured grey, with the CDR1 loop coloured yellow, the CDR2 loop coloured dark blue, and the CDR3 loop coloured red. The position of the GCase active site is indicated by an arrow. On the right: A close-up view showing some of the interactions between the Nb1 CDR1 loop (upper panel), the CDR2 loop (middle panel) and the CDR3 loop (lower panel) and GCase.Interacting residues are shown in stick representation. The structure and structure factors have been deposited in the PDB under the code 9ENA.
Beeld:
Dal Maso, Sinisgalli et al. (2025) Nat. Commun. 16, Open Access
