Structure of GCase-Nb1 complex
Left: Overall structure of the GCase-Nb1 complex. The three domains of GCase are colored in pink (domain 1 = three-stranded anti-parallel β-sheet domain), green (domain 2 = Ig-like domain), and light blue (domain 3 = (β/α)8 triose-phosphate isomerase (TIM) barrel). Nb1 is colored grey with the CDR1 loop in yellow, CDR2 loop in dark blue and CDR3 loop in red. The position of the active site of GCase is indicated with an arrow. On the right: Close up view of some of the interactions between the Nb1 CDR1 loop (upper panel), CDR2 loop (middle panel), and CDR3 loop (lower panel) with GCase. Interacting residues are shown in stick representation. The structure and structure factors were deposited in the PDB (code 9ENA).
Beeld:
Dal Maso, Sinisgalli et al. (2025) Nat. Commun. 16, Open Access
